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Literature summary extracted from
- Regulation of sterol 12alpha-hydroxylase and cholic acid biosynthesis in the rat (2000), Gastroenterology, 118, 599-607.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.139 | additional information | Rattus norvegicus | the enzyme is required for biosynthesis of cholic acid. CYP8b1 is transcriptionally down-regulated by hydrophobic but not hydrophilic bile acids. Cholesterol feeding and a single thyroid hormone injection repress CYP8b1 in face of cholesterol 7alpha-hydroxylase specific activities | ? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.139 | Rattus norvegicus | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.139 | additional information | the enzyme is required for biosynthesis of cholic acid. CYP8b1 is transcriptionally down-regulated by hydrophobic but not hydrophilic bile acids. Cholesterol feeding and a single thyroid hormone injection repress CYP8b1 in face of cholesterol 7alpha-hydroxylase specific activities | Rattus norvegicus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.139 | CYP8B1 | - |
Rattus norvegicus |
| 1.14.14.139 | sterol 12alpha-hydroxylase | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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